A model-free estimation for the covariate-adjusted Youden index and its associated cut-point
نویسندگان
چکیده
منابع مشابه
Nonparametric Bayesian covariate-adjusted estimation of the Youden index.
A novel nonparametric regression model is developed for evaluating the covariate-specific accuracy of a continuous biological marker. Accurately screening diseased from nondiseased individuals and correctly diagnosing disease stage are critically important to health care on several fronts, including guiding recommendations about combinations of treatments and their intensities. The accuracy of ...
متن کاملEstimation of the Youden Index and its associated cutoff point.
The Youden Index is a frequently used summary measure of the ROC (Receiver Operating Characteristic) curve. It both, measures the effectiveness of a diagnostic marker and enables the selection of an optimal threshold value (cutoff point) for the marker. In this paper we compare several estimation procedures for the Youden Index and its associated cutoff point. These are based on (1) normal assu...
متن کاملGeneralized Confidence Intervals for Partial Youden Index and its Corresponding Optimal Cut-Off Point
In the field of diagnostic test studies, the accuracy of a diagnostic test is essential in evaluating the performance of the test. The receiver operating characteristic (ROC ) curve and the area under the curve (AUC ) are widely used in such evaluation procedures. Meanwhile, the Youden index is also introduced into practice to measure the accuracy of the diagnostic test from another aspect. The...
متن کاملOptimal cut-point and its corresponding Youden Index to discriminate individuals using pooled blood samples.
Costs can hamper the evaluation of the effectiveness of new biomarkers. Analysis of smaller numbers of pooled specimens has been shown to be a useful cost-cutting technique. The Youden index (J), a function of sensitivity (q) and specificity (p), is a commonly used measure of overall diagnostic effectiveness. More importantly, J is the maximum vertical distance or difference between the ROC cur...
متن کاملEstimation of Youden Index and Its Associated Optimal Cut-point When the Parameters of Gamma Biomarkers Are Estimated by the Method of Moments
The ROC (Receiver Operating Characteristics) curves are frequently used to measure the effectiveness of diagnostic biomarkers. A global measure of the ROC curve is the Youden index, the maximum difference between sensitivity and 1-specificity. The cut-point is the value for which the maximum is attained. In this paper we obtain the asymptotic distribution of the optimal cut-point under the assu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2014
ISSN: 0277-6715
DOI: 10.1002/sim.6290